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Overview

Undecylenoyl phenylalanine, also known as acylamide, is a melanin-stimulating hormone (α-MSH) receptor antagonist. Generate signals to control the combination of α-MSH (melanocyte stimulating hormone) and melanin production factor, effectively inhibit the activity of tyrosinase, thereby inhibiting the formation of melanin. ,

Mainly used in cosmetics as a whitening agent.

Undecylenoyl phenylalanine (MoreWhiteUP) is a white powder. It is a structural analog of α-MSH, which can inhibit the activity of melanocytes and reduce the production of melanin by competitively binding to the melanin receptor MC1-R on melanocytes, so that melanocytes cannot produce tyrosinase.

• (1) Amide can effectively inhibit the formation of melanin caused by α-MSH, and can act on multiple stages of melanin formation to whiten or reduce the deposition of epidermal melanin, improve skin problems such as dark yellow and roughness, and even skin Skin tone, prevention, delay and treatment of hyperpigmentation in the skin (eg post-inflammatory hyperpigmentation, pigmentation such as age spots, etc.). [1-2]
• (2) Acylamide can be combined with nicotinamide, which can prevent melanin synthesis from the source (that is, inhibit melanin production signal and inhibit melanin production enzyme activity), while nicotinamide interferes with melanin synthesis pathway (that is, inhibits the transport of melanin to the stratum corneum. and accelerate the metabolism of melanin stratum corneum), cooperate with each other to exert the effect of whitening and lightening. It can be used to formulate stable and non-discoloring lotions, creams, transparent water preparations or gels, etc.

According to some clinical trials, Undecylenoyl Phenylalanine (MoreWhiteUChemicalbookP) does reduce pigmentation spots. Undecylenoyl phenylalanine has good skin affinity and can control the combination of α-MSH (melanocyte stimulating hormone) and melanin production factor, thereby blocking the process of melanin formation.

It can block α-MSH at 0.001% concentration, and the optimal concentration is 1%. Comprehensively inhibits melanin production from multiple links, and the effect is more obvious and lasting.