Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural dietary compound and the primary antioxidant component of blueberries. It has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect. Multiple studies have demonstrated the antioxidant activity of pterostilbene in both in vitro and in vivo models illustrating both preventative and therapeutic benefits.
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbenoid chemically related to resveratrol. In plants, it serves a defensive phytoalexin role. Pterostilbene is found in almonds, various Vaccinium berries (including blueberries), grape leaves and vines, and Pterocarpus marsupium heartwood.
Pterostilbene is a methylated stilbene molecule with structural similarity to resveratrol, the only difference being two methoxy groups on the pterostilbene molecule that replace hydroxy groups on the resveratrol molecule. While most of the actions of the two are comparable, pterostilbene appears to be much more well absorbed following oral ingestion and maybe a more potent antioxidant and anticancer molecule.
Scientists have also discovered the existence of Pterostilbene in other plants, but because of its first discovery of Pterostilbene species, it was named Pterostilbene. Pterostilbene is a white or almost white powder crystal, which has rich medicinal Chemicalbook value. It belongs to the antifungal active ingredient in Dragon's blood products and has certain effects on the treatment of cancer, hypertension, and hyperlipidemia. Recently, researchers have mastered the industrial synthesis method of pterostilbene.
Using 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde as raw materials, the target compound was obtained through Witting-Hornor reaction, reduction, diazotization, and hydrolysis, and the natural Chemicalbook multifunctional was synthesized with a total yield of 53.9%. The antioxidant pterostilbene and the structure of the target compound were characterized by IR, 1HNMR, and EI-MS. The synthesis process is simple, easy to operate, low production cost, and has good industrial application prospects.
Pterostilbene has antioxidant, anti-inflammatory, anti-thrombotic, anti-hyperlipemia, anti-cell proliferation, anti-bacterial, and many other activities, and can inhibit COX-1 and COX-2.
The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.
In the field of cosmetics, for anti-aging products：
Pterostilbene has significant antioxidant and free radical scavenging abilities similar to resveratrol. Studies in vivo and in vitro have confirmed that it has a strong role in scavenging oxygen free radicals and protecting cells. As an antioxidant, Pterocarpus stilbene can inhibit the generation of oxygen free radicals, scavenge and capture free radicals, protect DNA, protein, and other macromolecules from active oxygen damage.
- Promote overall brain health and healthy brain cells;
- Healthy cognitive, memory, and motor functions;
- Repair DNA due to the antioxidant effect, leading to healthy aging;
- Healthy blood sugar levels and blood circulation;
to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells) to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-4,5-dimethylthiazol-2-yl-2,5 diphenyl tetrazolium bromide)viability assay.
3',5'-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4'-hydroxy-E-stilbene, 3',5'-Dimethoxy-resveratrol
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Purity ≧99%, Raw Powder Or Ratio Extract Powder
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