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Palmitoyl Hexapeptide-12 is a six amino acid peptide that is claimed to improve firmness and skin tone. Its amino acid sequence is Val-Gly-Val-Ala-Pro-Gly that is also called the "spring fragment" and is repeated six times in the important skin protein, elastin molecule.

Palmitoyl Hexapeptide-12 (Sequence: Pal-Val-Gly-Val-Ala-Pro-Gly), also known as palmitoyl oligopeptide, is a lipopeptide molecule in biopeptide-EL, and a signal peptide. Unlike water-soluble peptides, palmitoyl Hexapeptide-12 is highly biocompatible with skin's natural structure. It boosts cell's natural productivity level and is considered to be one of the most natural powerful antiagers.

Palmitoyl hexapeptide-12 is a signal peptide belonging to the Matrikine series, which is particularly involved in repairing age-related skin damage and promoting dermal fibroblast migration, proliferation, and matrix macromolecular synthesis (eg, elastin, collagen, etc.). It provides support for the skin. It also induces fibroblasts and monocytes to specific locations for wound repair and tissue renewal. Studies have shown that it can reduce the production of interleukin-6 (IL-6) in key skin cells, keratinocytes and fibroblasts.

In conclusion, as an active agent of cosmetic, palmitoyl hexapeptide-12 may be used individually or in combination with one or more other peptides.