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Active ingredients

The species is known to produce many alkaloids including catharanthine, coronaridine, dregamine, ibogamine, tabersonine, voacangine, voacamine and voacristine. Ibogaine, which is said to occur in multiple Tabernaemontana species as well as 10,11-Demethoxychippiine which is a rare chippiine-dippinine compound is found in stem bark extract of this plant in minor concentrations.

Extraction processing method

Tabernaemontana Divaricata flower needs to be extracted with water or alcohol. Concentrated, spray-dried into powder, sieved, sterilized, and packaged.

Pharmacology

The whole plant(Tabernaemontana Divaricata Extract) contains indole alkaloids, and the seeds contain indole alkaloids, which have the effects of diuresis and swelling, cooling and relieving heat, clearing heat, and lowering blood pressure.

In traditional Chinese medicine, Tabernaemontana Divaricata can be used as medicine. There are many alkaline components in it, especially the highest content in roots and stems. Its most important medicinal effects are heat-clearing, reducing blood pressure, and detoxifying and reducing swelling.

It is usually used for the treatment of various diseases such as postpartum qi and blood deficiency, dizziness and constant milk. In treatment, decoction is the mainstay, and the dosage is about ten grams.

Application in cosmetics&skin care products

There is presence of potent acetylcholinestearase inhibitors in stems and roots of this plant. 3'-R/S-hydroxyvoacamine isolated from a stem extracts act as a non-competitive inhibitor against AChE with an IC50 value of 7.00±1.99 μM. Bisindole alkaloid 19,20-dihydrotabernamine and 19,20-Dihydroervahanine A shows higher inhibitory activity on acetylcholinesterase compared with galanthamine.