Mexoryl(Ecamsule)

Mexoryl(Ecamsule)

Other names : Ecamsule; Mexoryl SX; Terephthalylidene dicamphor sulfonic acid
CAS # : 92761-26-7
Molecular formula : C28H34O8S2 
Molar mass : 562.69 g mol−1 
Characteristics and Application :
Mexoryl has been marketed as a breakthrough ingredient, providing protection that is said to be far more comprehensive than commonly used UVA filters such as Oxybenzone, Titanium Dioxide or Parsol 1789. The ingredient has been licensed for use in Europe since 1993, where it is generically known as ecarnsule, and is incorporated into a number of leading sunscreen products.
Ecamsule (USAN, trade name Mexoryl SX, INCI terephthalylidene dicamphor sulfonic acid) is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability.
Although there are a few different UV absorbers with the trade name Mexoryl, only two of them are widely used where approved. Mexoryl SX (water soluble) and Mexoryl XL (INCI Drometrizole trisiloxane, oil soluble). Together they show a synergistic effect in protection.
Mode of action :
Exposed to UV, ecamsule undergoes reversible photoisomerization, followed by photoexcitation. The absorbed UV is then released as thermal energy, without penetrating the skin.
UVB rays cause short-term sunburn and skin cancer; UVA rays cause wrinkling and may have some role in development of skin cancer. There is no official rating for UVA protection in the US. In Europe, there are several different rating systems that are used to measure effectiveness in blocking UVA rays, including the IPD (immediate pigment darkening assay) and the PPD (persistent pigment darkening assay). The UVB range is 280 to 320 nanometers, and the UVA range is 320 to 400. Ecamsule protects against UV wavelengths in the 290–400 nanometer range, with peak protection at 345 nm.[3][4] Since ecamsule doesn't cover the entire UV spectrum, it should be combined with other active sunscreen agents to ensure broad-spectrum UV protection. Ecamsule is a photostable organic UVA absorber, meaning it doesn't degrade significantly when exposed to light. This is in contrast to the widely used UVA absorber avobenzone that is not intrinsically photostable and requires photostabilizers to prevent significant degradation in light.
Efficacy :
A 5% ecamsule containing sunscreen can prevent early changes leading to photoaging in humans. A broad spectrum sunscreen with ecamsule, avobenzone and octocrylene significantly reduces the skin damage associated with UV exposure in human subjects.
In studies done in mice it reduces the formation of UV induced pyrimidine dimers and delays the onset of skin cancer. In vitro ecamsule effectively protects against the harmful effects of UV.

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