Other name : Dichloroethanoic acid / Bichloroacetic acid
CAS # : 79-43-6
Molecular formula C2H2Cl2O2/CHCl2COOH
Molar mass 128.942 g/mol
Appearance colorless liquid
Density 1.5634 g/cm3 at 20°C
Melting point 13.5°C
Boiling point 194°C
Solubility in water miscible
Solubility miscible with ethanol, diethyl ether
Acidity (pKa) 1.25
Dichloroacetic acid, often abbreviated DCA, is a chemical compound, an acid, and an analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates.
The chemistry of dichloroacetic acid is typical for halogenated organic acids. It is a member of the chloroacetic acids family,pure dichloroacetic acid is very corrosive and extremely destructive to tissuesof the mucous membranes and upper respiratory tract.
Owing to the highly corrosive action of the acid, only the salts of dichloroacetic acid are used therapeutically, including its sodium and potassium salts, sodium dichloroacetate and potassium dichloroacetate.
Use for Lactic acidosis and Potential cancer applications.
A randomized controlled trial of DCA in adults with lactic acidosis found that while DCA lowered blood lactate levels.
The promise of DCA as a cheap, effective and safe treatment for cancer generated a great deal of public interest.
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