Cholecalciferol

Cholecalciferol

Other names : vitamin D3, activated 7-dehydrocholesterol
Items                           Properties

Molecular formula     C27H44O 
Molar mass                384.64 g/mol 
Appearance               White, needle-like crystals 
Melting point              83–86 °C 
Description : 
Cholecalciferol is a vitamin D3. Cholecalciferol is the naturally occurring form of vitamin D. It is a prehormone that is synthesized naturally in the skin by ultraviolet B irradiation of 7-dehydrocholesterol. Cholecalciferol is real vitamin D. All other compounds are either metabolic products or chemical modifications.Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.
 A combination of cholecalciferol and alendronate was approved by FDA for the treatment and prevention of osteoporosis. 
Action :
Cholecalciferol is vitamin D3 which is required for normal bone formation. It is converted to 25-hydroxyvitamin D3 in the liver and then further converted to 1,25-dihydroxyvitamin D3 (calcitriol) in the kidney. This conversion is stimulated by parathyroid hormone and hypophosphatemia. As a result, 1,25-dihydroxyvitamin D3 increases the absorption of calcium and phosphate in the intestines. 
Use : 
Cholecalciferol is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones.
Cholecalciferol may also be used for other purposes not listed in this medication guide.
Side effects : 
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking cholecalciferol and call your doctor at once if you have a serious side effect such as: 
thinking problems, changes in behavior, feeling irritable; 
urinating more than usual; 
chest pain, feeling short of breath; or 
early signs of vitamin D overdose (weakness, metallic taste in your mouth, weight loss, muscle or bone pain, constipation, nausea, and vomiting). 
This is not a complete list of side effects 
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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